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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3R2
All Species:
7.88
Human Site:
S262
Identified Species:
19.26
UniProt:
O00459
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O00459
NP_005018.1
728
81624
S262
L
R
A
P
P
P
P
S
S
P
P
P
G
G
A
Chimpanzee
Pan troglodytes
XP_001161374
718
82840
T261
F
R
F
S
P
P
P
T
L
Q
P
Y
G
S
C
Rhesus Macaque
Macaca mulatta
XP_001114094
727
81552
S261
L
L
R
A
P
P
P
S
S
P
P
P
G
G
A
Dog
Lupus familis
XP_852406
939
103719
P473
L
L
L
R
A
P
P
P
S
P
P
P
G
G
A
Cat
Felis silvestris
Mouse
Mus musculus
O08908
722
81233
R256
A
F
G
P
L
L
L
R
I
P
P
S
G
G
E
Rat
Rattus norvegicus
Q63788
722
81310
R256
A
F
G
P
L
L
L
R
A
P
P
P
G
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511081
737
83223
S272
L
L
L
R
L
P
I
S
G
Y
V
P
G
G
A
Chicken
Gallus gallus
XP_001233341
737
84002
L277
L
R
L
P
G
S
P
L
Q
L
L
I
R
S
S
Frog
Xenopus laevis
Q8UUU2
722
83110
F267
A
K
S
L
A
E
I
F
S
P
L
L
F
R
I
Zebra Danio
Brachydanio rerio
NP_997987
723
82797
R268
I
F
G
P
L
L
F
R
G
P
V
S
G
S
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
61.2
98.7
75.4
N.A.
89.4
88.3
N.A.
73
72
59.7
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
76.2
99
75.9
N.A.
93.2
92.7
N.A.
82.2
82.3
74.7
75.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
40
80
66.6
N.A.
33.3
40
N.A.
46.6
26.6
13.3
20
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
46.6
80
66.6
N.A.
33.3
46.6
N.A.
46.6
33.3
26.6
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
30
0
10
10
20
0
0
0
10
0
0
0
0
0
40
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
30
% E
% Phe:
10
30
10
0
0
0
10
10
0
0
0
0
10
0
0
% F
% Gly:
0
0
30
0
10
0
0
0
20
0
0
0
80
60
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
20
0
10
0
0
10
0
0
10
% I
% Lys:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
50
30
30
10
40
30
20
10
10
10
20
10
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
50
30
50
50
10
0
70
60
50
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
10
0
0
0
0
0
% Q
% Arg:
0
30
10
20
0
0
0
30
0
0
0
0
10
10
0
% R
% Ser:
0
0
10
10
0
10
0
30
40
0
0
20
0
30
10
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
20
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _